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A used alloy wheels that fits one vehicle won't always fit another - even within the same model range. These questions help breakers match stock to your exact vehicle before they quote:
The W220 and W221 are separate generations with different specifications, and the bolt pattern, offset, and centre bore can differ between them, so fitment across this generational boundary is not guaranteed. You should confirm with the breaker against your exact registration before buying, as what fits one generation does not automatically cross over to the next.
The W222 ran from 2013 to 2020, with a facelift arriving in 2017, and because both pre- and post-facelift cars share the same generation, alloys generally interchange within the W222 as long as the PCD, offset, and centre bore match. This makes used W222 alloys a practical option across the full 2013–2020 range, but always confirm the exact specifications with the breaker against your registration to be sure.
Engine size does not affect alloy wheel fitment on the S-Class, so an S350, S500, or S63 AMG from the same generation will share the same bolt pattern and centre bore. However, AMG and AMG Line trims often came with larger diameter wheels and different offsets compared to standard SE or Exclusive spec cars, so while the bolt pattern may match, the offset and tyre size combination may differ — confirm the specific offset of any used set with the breaker against your registration.
The W223 launched in 2020 as a new generation and the specifications are unlikely to be a straightforward match for the W222, making this a cross-generation fitment question. Confirm PCD, offset, and centre bore with the breaker against both registrations before purchasing, as assuming compatibility across this boundary could mean the wheels do not fit safely.
Most S-Class models are fitted with tyre pressure monitoring systems, and used alloys from a breaker may or may not include compatible TPMS sensors. Whether a sensor from a donor car will work with your vehicle's system depends on your specific car's setup, so you should confirm TPMS sensor compatibility with the breaker against your registration rather than assuming the sensors will carry over.
Mercedes-Benz has used shared PCD and centre bore specifications across several model lines in the same period, so E-Class and S-Class alloys from the same generation sometimes do interchange, but offset and diameter can differ between the two models. Check the exact PCD, offset, and centre bore of the specific set with the breaker and confirm against your registration before buying.