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Fitment on a used wheel hub varies by vehicle, so a bit of detail goes a long way. Our request form covers what breakers need to know, so every quote you get back is for the correct part:
The current W222 S-Class ran from 2013 to 2020, with a facelift in 2017, so a 2014 and a 2018 are in the same generation but on opposite sides of that facelift boundary. The hub mounting and bearing arrangement is generally consistent across the W222, but whether the pre-facelift and post-facelift hubs interchange exactly — particularly if brake sizes changed at the refresh — is something you should confirm with the breaker against your specific registration before ordering.
The W221 ran from 2005 to 2013 and the W222 from 2013 to 2020, so these are distinct generations with different platform architecture. Hub dimensions, bolt patterns and bearing interfaces changed between generations, making a straight swap very unlikely. Always give the breaker both registration numbers so they can verify compatibility rather than relying on a visual match.
Yes, engine size can matter for S-Class hubs because larger, more powerful variants — such as the S500 or S63 AMG — are typically fitted with bigger brake assemblies, and the hub must correspond to that brake package. An S350 hub may not share the same specification as an S63 hub even within the same W222 generation. Always tell the breaker your exact engine and, ideally, your VIN so they can pull the correct hub spec.
For the W222 generation the S-Class L (long wheelbase) variant shares the same front and rear suspension geometry and hub design as the standard wheelbase car, so wheelbase alone should not affect hub fitment. The bigger fitment variables remain engine size and brake package, not body length. Confirm the exact spec with the breaker using your registration to be certain.
Trim levels such as AMG Line are primarily cosmetic packages covering interior upgrades, styling addenda and alloy wheel designs, and they do not change the underlying hub specification. What does matter is whether your car has an AMG performance variant like the S63 or S65, which carry uprated braking systems requiring their own matching hubs. If you have a pure trim-level upgrade rather than a full AMG model, the hub from an equivalent non-AMG-trim car of the same engine and generation should correspond — but always confirm with the breaker against your registration.
For most S-Class wheel hubs the hub itself is the same unit left and right, as the bearing and flange are symmetrical. However, if your car is fitted with an ABS sensor or wheel speed sensor integrated into or attached to the hub assembly, you should check whether the sensor routing differs between the nearside and offside before buying. Ask the breaker to confirm whether the hub they have includes the sensor and whether it was pulled from the same side as the one you need.