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No two rear panels are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
No — the W220 (1998–2005) and W221 (2005–2013) are entirely different generations with completely different body pressing, so the rear panels are not interchangeable. Each generation has its own unique rear end geometry and shut lines, and parts must be sourced from the correct generation to fit. Always confirm the exact generation code with your breaker against your registration number.
No — engine choice and trim level, including AMG Line, AMG 63 or standard SE/S350/S500 designations, do not change the rear panel pressing on the S-Class; the body shell is the same across those variants within a given generation. You may find the existing panel on an AMG car carries different badging holes or finisher cutouts, so factor in a small cosmetic difference when sourcing from a non-AMG donor car. Confirm any specific cutout or badge-hole differences with your breaker before buying.
The W221 ran from 2005 to 2013 and received a facelift in 2009, so a 2010 and a 2012 car are both post-facelift and should share the same generation body. Whether Mercedes introduced any mid-run pressing changes between those specific years is something you should confirm with the breaker against your registration, as subtle updates can occur without a formal model-year change. Treat the facelift boundary (pre-2009 vs 2009-on) as the key dividing line and verify across it with your breaker rather than assuming interchange.
The W221 generation spans 2005 to 2013 with a significant facelift in 2009, and while the underlying platform is shared, the rear bodywork styling changed at that facelift point. Whether the panel pressings are dimensionally compatible enough to swap across the 2009 facelift boundary is not something that can be confirmed without checking your specific car — route this directly to the breaker and have them check against your registration before purchasing.
The W222 S-Class ran from 2013 to 2020 and was sold in a long-wheelbase (LWB) variant alongside the standard-wheelbase car, so you must confirm whether both donor and recipient are the same wheelbase before sourcing. Beyond wheelbase, whether there are any pressing differences between market variants sold under the same W222 platform is something you should confirm with the breaker against your registration, as subtle regional differences can exist. Stick to UK-sourced or clearly identified standard-wheelbase W222 panels wherever possible to reduce risk.
No — the engine variant (S350, S450, S500 and so on) has no bearing on which rear panel is fitted; the body pressing is the same across those derivatives within a given generation. What does matter is the generation (for example W220, W221, or W222) and the wheelbase (standard or long), so always match those first. Confirm the exact spec against your registration with your breaker before agreeing a purchase.