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No — the W220 (2000–2005) and W221 (2006–2013) are entirely different generations with different steering columns, clock springs, and SRS systems, so the airbags are not interchangeable. Always source a bag from the correct generation for your car. Confirm exact module compatibility with the breaker against your registration before buying.
Both years fall within the W221 generation (2006–2013), so the physical steering wheel design is broadly the same and fitment is more likely than across generations. However, the W221 received a facelift in 2009 which brought interior updates, so confirm with the breaker whether the airbag is from a pre-facelift or post-facelift car and check it matches your own. Always confirm SRS module compatibility against your registration with the breaker before purchasing.
Engine variant makes no difference here — the steering wheel airbag fitment is determined by generation and trim/equipment level rather than engine size, so an S350 and S500 from the same generation will typically share the same airbag if they share the same steering wheel. AMG models may have a different sport steering wheel with a different airbag module, so if your car has an AMG or AMG Line steering wheel, confirm this with the breaker. Never assume fitment without checking your specific wheel against the donor car.
Airbags are safety-critical, single-use components — once deployed they cannot be reused, so you must only buy a used airbag that has never been triggered and is confirmed undeployed. A reputable breaker will be able to confirm the status of the airbag before sale. Professional fitting by a qualified technician is strongly recommended, as incorrect installation can cause the airbag to fail to deploy or to deploy unexpectedly.
No — the W222 (2013–2020) and W223 (2020–present) are separate generations with different steering wheel designs and SRS systems, so parts from one will not transfer to the other. Source the airbag specifically for your generation, and confirm module compatibility with the breaker against your registration before ordering.
The wheelbase variant — standard, long wheelbase, or Maybach — does not affect the steering wheel or its airbag, as these are determined by generation and interior trim specification rather than body length. However, if your car has a unique or upgraded steering wheel fitted as part of a high-specification or Maybach package, confirm the exact wheel specification with the breaker to ensure the airbag matches. Always have a used airbag inspected and fitted by a qualified professional.