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No two window regulators are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The ML has had three main generations: the W163 (1998–2005), the W164 (2005–2011), and the W166 (2011–2019). Window regulators are generation-specific because the door frames and mechanism mountings changed between each, so you must match the part to your generation. Check your registration on the DVLA or V5C to confirm which generation you have before approaching a breaker.
These are from different generations — the 2004 model is a W163, while the 2006 model is a W164 — and the door structures changed between them, so they are very unlikely to be interchangeable. You should confirm the exact part number and fitment with the breaker against your specific registration before buying.
Yes, it matters significantly — the nearside (NS, passenger/left) and offside (OS, driver/right) regulators are handed parts and will not swap between sides. When contacting a breaker, always specify clearly whether you need NS or OS, as well as whether it is front or rear, to ensure you get the correct unit.
No, the engine or trim designation (such as ML270, ML350, or ML500) does not affect window regulator fitment, as the door frame and mechanism are the same across the range within a generation. You may find cosmetic differences in door furniture between trim levels, but the regulator itself is determined by generation, door position, and side (NS or OS).
The W164 received a facelift around 2008, but whether this changed the window regulator mechanism is not something we can state with certainty. Name the exact year of your vehicle to the breaker and ask them to check the part number against your registration, as fitment across a facelift boundary should always be confirmed rather than assumed.
Both are within the W166 generation (2011–2019), so they share the same basic platform and door structure, which is a good sign for compatibility. However, you should still confirm the specific door position (front or rear) and side (NS or OS) with the breaker, and ask them to verify against your registration plate to be certain.