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A used radio that fits one vehicle won't always fit another - even within the same model range. These questions help breakers match stock to your exact vehicle before they quote:
No — the W220 (1998–2005) and W221 (2005–2013) are completely different generations with different dashboard architecture, wiring connectors, and control systems, so radios do not interchange between them. Always confirm the exact part with the breaker against your registration to be sure.
The W221 ran from 2005 to 2013 with a facelift in 2009, and Mercedes updated the infotainment system at that point, meaning pre-facelift (2005–2009) and post-facelift (2009–2013) units may differ in connectors and software. Whether a specific unit crosses that 2009 boundary depends on the exact part number, so route this one to the breaker to confirm against your registration.
The W222 ran from 2013 to 2020 (facelift 2017) and the W223 launched in 2020, bringing a fundamentally different MBUX infotainment architecture, so these units are not compatible. Confirm with the breaker against your registration before ordering.
Trim level alone does not determine radio fitment on the S-Class; what matters is the generation, facelift phase, and the specific head unit or Command system fitted. Bear in mind that higher trims or AMG-badged cars may have been optioned with a different screen size or upgraded audio system, so there could be cosmetic or functional differences to the unit you receive — confirm the exact spec with the breaker against your registration.
The 2017 facelift brought updates to the Command Online infotainment system on the W222, and while the generation is the same, connector and software differences mean a pre-facelift unit may not work correctly in a post-facelift car. Confirm with the breaker whether the specific part number is compatible with your exact registration before buying.
The radio unit itself is not affected by wheelbase length — the LWB S-Class shares the same dashboard and infotainment hardware as the standard-wheelbase car within the same generation and facelift phase. What matters is the generation, facelift year, and the specific Command system spec, so confirm those details with the breaker against your registration.