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The W221 S-Class ran from 2005 to 2013, with a facelift in 2009 that brought a restyled grille and front end. Grilles from pre-facelift W221s (2005–2009) should interchange with other pre-facelift cars, and post-facelift grilles (2009–2013) should fit other post-facelift cars within that same generation. Whether a pre-facelift grille can be made to fit a post-facelift car (or vice versa) is not straightforward — confirm that with the breaker against your registration before buying.
The W222 S-Class ran from 2013 to 2020, with a facelift in 2017 that updated the front end including the grille surround and bumper design. A 2014 grille sits in the pre-facelift W222 period (2013–2017), while a 2018 model is post-facelift, so they do not share the same front-end styling. Confirm with the breaker against your exact registration whether the specific panel you're looking at crosses that 2017 facelift boundary, as fitment across it is not guaranteed.
For front grille fitment purposes, the generation and facelift period are what matter — not the trim level. That said, AMG Line and AMG-badged S-Classes may use a visually different grille style (typically a Panamericana or sportier surround), so a standard grille sourced from a non-AMG car may look noticeably different on your vehicle even if it physically fits. Confirm with the breaker which trim the donor car was, so you end up with the right look for your car.
Yes — on the S-Class, the front grille and front-end panels are shared across wheelbase variants within the same generation and facelift period. The long-wheelbase (often badged L in the UK) only differs behind the B-pillar, so a grille from a standard-wheelbase car will be the same part as one from the long-wheelbase version of the same year. Just ensure you're matching the correct generation and facelift period rather than worrying about wheelbase.
No — the W220 (1998–2005) and W221 (2005–2013) are entirely different generations with different front-end designs, and their grilles are not interchangeable. Always match the grille to the correct generation; the W220 and W221 share no front-end panels. Source a W221 grille and make sure it also matches the correct facelift period for your car (pre-facelift 2005–2009 or post-facelift 2009–2013).
No — the engine has no bearing on front grille fitment for the S-Class; the grille is the same across the engine range within a given generation and facelift period. Focus instead on matching the generation (for example W220, W221 or W222) and whether the donor car is pre- or post-facelift. Trim-related cosmetic differences such as AMG-style grille surrounds are worth checking with the breaker, but engine choice can be disregarded entirely.