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No two engines are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The CLK ran across two main generations: the W208 (1997–2002) and the W209 (2002–2009), with the W209 receiving a facelift in 2005. These are meaningfully different platforms, so an engine from a W208 will not simply drop into a W209 without significant work, and vice versa. Always confirm the generation by checking the chassis code on your V5 or a VIN check before approaching a breaker.
Both years sit within the W209 generation, but 2004 is pre-facelift and 2006 is post-facelift (the facelift landed in 2005), which can mean ancillary and mounting changes even though the core engine architecture may be shared. The most reliable way to confirm interchange is to match the engine code exactly — found on your V5 or via a VIN check — and then put that code to the breaker against your registration. Never assume fitment solely on year proximity across a facelift boundary.
The CLK 320 and CLK 350 both appeared in the W209 generation but use different engines — the 320 uses a V6 M112 unit while the 350 uses a V6 M272, so they are not the same engine and will not swap directly. The badge or displacement number is less reliable than the engine code itself, which you should pull from your V5 or a VIN check. Confirm the exact code with the breaker before purchasing.
Trim level alone does not determine engine fitment on the CLK; what matters is your engine code, fuel type, and gearbox type, not whether your car is an Elegance or Avantgarde. A used engine from an Avantgarde with the same engine code as your Elegance is mechanically equivalent for this purpose, though minor ancillary differences are possible and worth confirming with the breaker. You may also find cosmetic or interior differences on a donor car that are irrelevant to the engine swap itself.
No — petrol and diesel engines are entirely different units and are not interchangeable, regardless of year or generation. Always confirm your fuel type matches the donor engine, and supply the breaker with your engine code to make sure they are quoting the correct unit. Mixing fuel types would also involve significant ancillary, ECU, and fuel system incompatibilities.
This is a real consideration on Mercedes-Benz vehicles and one you should raise directly with the breaker and your fitting garage rather than assume it is straightforward. Whether an engine ECU needs coding or pairing to your car depends on specifics we cannot confirm here as a blanket fact. Ask the breaker whether the ECU is included, and clarify with your mechanic whether coding will be required before committing to a purchase.