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A used ignition switch that fits one vehicle won't always fit another - even within the same model range. These questions help breakers match stock to your exact vehicle before they quote:
It depends on the generation. Earlier S-Class models such as the W220 (1998–2005) and W221 (2005–2013) used a conventional barrel-type ignition switch where you insert and turn a physical key. The W222 (2013–2020) and later X223 (2020-onwards) generations moved to keyless ignition systems, so a traditional ignition switch barrel as such does not apply to those cars in the same way.
No — the W220 (1998–2005) and W221 (2005–2013) are separate generations with different ignition assemblies, and parts from one will not simply transfer to the other. You need a switch sourced specifically from the W221 generation to have any realistic chance of compatibility. Confirm the exact part number with the breaker against your registration before purchasing.
Trim level — whether that's an SE, AMG Sport, or AMG Line specification — does not affect the ignition switch fitment, as it is a mechanical and electrical component unrelated to interior trim. Engine choice (petrol, diesel, or V12) could potentially affect the associated electronic coding, so confirm with the breaker that the switch from their donor car matches your specific engine variant and registration before buying.
The W220 received a facelift around 2002, but the ignition switch assembly is not typically one of the components changed at a facelift point. In practice, a switch from a pre-facelift W220 may well fit a post-facelift car, but because electronic variants and coding differences can exist across production runs, you should confirm compatibility with the breaker against your registration rather than assume it is a straight swap.
The W221 was facelifted in 2009, and while the ignition switch is not a body or styling component, subtle changes to wiring and electronic control modules across a facelift can sometimes affect compatibility. It is worth telling the breaker exactly which year your car is and asking them to check the part number on their donor vehicle against yours before they pull the part.
The W222 uses a keyless push-button start system rather than a traditional rotating ignition switch, so the component you may actually need is the start/stop button assembly, the EIS (Electronic Ignition Switch) module, or a related steering column electronic module rather than a conventional barrel switch. These components are often coded to the original vehicle, so a used part from a breaker will very likely need to be programmed to your car by a Mercedes specialist or dealer — confirm this with both the breaker and your chosen installer before purchasing.