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The W220 ran from 1998 to 2005, the W221 from 2005 to 2013, and the W222 from 2013 to 2020 — each generation uses a completely different tailgate with no crossover between them, so you must match the generation exactly. The S-Class in this era is a saloon (four-door), so there is no tailgate in the traditional hatchback sense; what buyers are usually sourcing is the boot lid, which is unique to each platform. Always quote your full registration to the breaker to confirm the correct generation.
Both a 2006 and a 2009 car fall within the W221 generation (2005–2013), so the platform is the same and fitment is more likely than across a generation boundary. However, the W221 received a facelift in 2009 which may have brought pressing or lamp-aperture changes to the boot lid, and whether the pre-facelift and post-facelift panels are interchangeable is something you should confirm with the breaker against both registrations before buying.
Trim level does not determine boot lid fitment on the S-Class — an SE, AMG Line, or L long-wheelbase variant all share the same basic panel within the same generation. You may find cosmetic differences such as badging, emblem holes, or camera cut-outs depending on the specification, so check the used panel matches your own car's features before agreeing a price. The generation and any facelift status matter far more than the trim name.
On the W221 and W222 generations, the long-wheelbase (S-Class L) has a longer rear overhang, but the boot lid itself sits at the rear of the bodywork and is generally the same pressing as the standard car — the extra length is in the rear doors and floor rather than the lid. That said, you should confirm this with the breaker against your specific registration, as subtle differences between standard and long-wheelbase rear panels are the kind of detail that can vary and is best checked before purchase.
The W222 generation ran from 2013 to 2020 and received a facelift in 2017, which introduced styling changes to the rear of the car including the boot lid and lamp design. A 2014 pre-facelift boot lid and a 2018 post-facelift boot lid are therefore from either side of a known styling boundary, and whether they interchange is not something we can confirm as fact — take both registrations to the breaker so they can check the exact part numbers before supplying.
No — whether your S-Class is a 350d, 500, 63 AMG, or any other engine variant, the engine has no bearing on boot lid fitment whatsoever. Match the generation (W220, W221, or W222), confirm the facelift status, and check for any spec-specific features such as parking camera apertures or badge holes on the used panel.