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Fitment on a used timing chain varies by vehicle, so a bit of detail goes a long way. Our request form covers what breakers need to know, so every quote you get back is for the correct part:
These are from different generations — the W221 ran from 2005 to 2013, and the W222 started in 2013 — so the answer depends heavily on whether the engine codes match, not just the year. Even within the same generation, Mercedes used several different engine families (petrol inline-sixes, V6, V8, V12, and diesel variants), each with their own timing chain setup. If the engine codes are identical, there is a reasonable chance of fitment within the same generation, but crossing the W221-to-W222 boundary means you should confirm compatibility with the breaker against your exact registration before purchasing.
Almost certainly not — the S350 and S500 use fundamentally different engines (a V6 or straight-six versus a V8), so their timing chains are not interchangeable regardless of the year or generation. The badge tells you the engine displacement, but the engine code is the definitive reference, and you should supply that to the breaker rather than relying on the model designation alone. Trim level and body style make no difference here; it is purely the engine that determines which timing chain you need.
The vast majority of S-Class engines across all generations use a timing chain rather than a rubber cam belt, including the petrol V6, V8, V12, and the common diesel engines such as the OM642 and OM651 units. This applies across the W220, W221, W222, and W223 generations, so a used timing chain is a genuine and commonly sourced part for this model. If you are unsure which engine you have, check your V5 or run a VIN check to get the engine code before approaching a breaker.
No — trim level has no bearing whatsoever on timing chain fitment. AMG Line, SE, and the long-wheelbase L variants are cosmetic or chassis distinctions, and the engine underneath is what dictates the chain specification. Give the breaker your engine code rather than your trim badge, and they will be able to match the part correctly.
The W221 ran from 2005 to 2013 with a facelift in 2009, and while many engine codes carried across that facelift, there is a possibility of ancillary or mounting changes around that point that could affect exact fitment. If your engine code matches the donor vehicle's engine code exactly, fitment within the W221 generation is likely, but you should confirm with the breaker against your registration — particularly if the donor car is from the other side of the 2009 facelift. Supplying your full engine code gives the breaker the best chance of finding you a compatible unit.
The W220 (1998–2005) and W221 (2005–2013) are different generations and the engines, while sometimes sharing a family lineage, went through significant development between them, making direct chain interchangeability unlikely even where displacement looks the same. Engine code is the only reliable guide here, and crossing a generation boundary like this means you must confirm compatibility with the breaker against both registrations before buying. Do not assume a match based on badge or engine size alone.