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No two steering boxs are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The S-Class (W220, W221, W222 generations) uses a recirculating-ball steering box rather than a rack-and-pinion system, which is typical for large luxury saloons of this class and size. So yes, a steering box is a genuine part on this model and is available from breakers. This is worth knowing because searching for a 'steering rack' on an S-Class will lead you to the wrong part entirely.
The W220 and W221 are different generations with different subframes, steering geometry and power-assisted steering systems, so the steering boxes are not a straight swap between them. You should source a steering box from the correct generation to match your car. Confirm the exact part number with the breaker against your registration to be certain of compatibility.
On the S-Class, the steering box can vary between engine variants because larger, heavier engines place different demands on the steering system, and some AMG or high-output models may have different specification boxes. Always tell the breaker your exact engine size and model code (for example S320, S500, or S63 AMG) rather than just the year. Confirm compatibility against your registration before ordering.
Trim level names like S350 or S500 on the S-Class reflect engine size, and on this model engine size can influence the steering box specification due to differences in vehicle weight and system demands. This is not a case where trim is purely cosmetic — the engine variant is a meaningful fitment factor here. Give the breaker your full model designation and registration so they can match the correct unit.
The W221 ran from 2005 to 2013 with a facelift around 2009 that brought various updates, and it is not certain whether the steering box changed specification across that facelift boundary. Name the facelift year to your breaker and confirm against your specific registration and VIN, as this is exactly the kind of mid-generation detail that is best verified with someone who has the physical part in front of them. Do not assume pre- and post-facelift boxes are interchangeable without that check.
It matters a great deal, because steering boxes on the S-Class can differ by generation, engine size and potentially by build date around facelift years, so a breaker who can check the part against your registration and VIN will give you the most reliable match. Findapart lets you get quotes from multiple UK breakers, so you can ask each one to confirm compatibility with your specific vehicle before committing. Never fit a steering component without being confident it is the correct specification for your car.