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Fitment on a used door card varies by vehicle, so a bit of detail goes a long way. Our request form covers what breakers need to know, so every quote you get back is for the correct part:
No — the W220 (1998–2005) and W221 (2006–2013) are entirely different generations with different door structures, so their door cards are not interchangeable. Always match the door card to the correct generation by checking the W-code on your registration documents or with the breaker.
Yes, it matters — NS (nearside, passenger left) and OS (offside, driver right) door cards are mirror images of each other and will not fit the opposite side. When ordering, confirm clearly whether you need NS or OS, and a good breaker will ask for this as standard.
The W222 ran from 2013 to 2020 with a facelift in 2017, and while the basic door shell remained the same generation, internal trim panel fixings and feature cutouts can differ across that facelift boundary. Name the facelift year to your breaker and confirm the part against your registration before buying.
The trim level itself does not change the fundamental fitment of the door card to the door frame, but AMG Line, SE, and other trim variants on the S-Class can have different speaker grille cutouts, switch blanks, and interior finishes. The card will physically mount the same way, but confirm any feature cutouts with the breaker so you get a like-for-like match.
A 2010 S-Class is a W221 (2006–2013), not a W220 (1998–2005), so it matters a great deal — the two generations have completely different door cards that will not interchange. Quote your full registration to the breaker so they can pull the exact donor vehicle match.
Colour does not affect fitment — the door card will mount correctly regardless of the original interior colour, and trim panels can be re-trimmed or replaced to match your interior. Focus on getting the correct generation, side (NS or OS), and feature cutouts right, and treat colour as a cosmetic consideration to sort separately.