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No two door cards are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The current Mercedes-Benz V-Class is the W447, which launched in 2014 and received a facelift in 2019 — door cards from within the same pre-facelift (2014–2019) or post-facelift (2019–present) period are the most likely to interchange directly, but whether a card crosses that 2019 facelift boundary is something you should confirm with the breaker against your registration, as interior panel designs can change at a refresh.
Yes, side matters — door cards are handed, so you need to specify NS (nearside, passenger/left) or OS (offside, driver/right) when requesting a quote from the breaker. Fitting the wrong side simply will not work, as the panel is shaped and clipped specifically for its aperture.
No, they are not the same — the sliding rear door on a V-Class has a different shape, clip layout, and internal architecture to a hinged door, so the cards are not interchangeable between those two door types. Make sure you tell the breaker whether you need a card for the sliding door or a hinged door, and for sliding doors also confirm your wheelbase (standard or long), as that can affect the panel.
Trim level does not affect the physical fitment of the door card — the mounting points and aperture are the same across Sport, AMG Line, and other standard V-Class grades. There can be cosmetic differences such as stitching style, material finish, or speaker grille design between trims, so the card from a different trim will fit but may look slightly different to your other doors; this is a cosmetic consideration, not a fitment one.
The 2016 car is a pre-facelift W447 and the 2021 is a post-facelift W447 (facelift from 2019), so these sit on either side of that generation boundary — the door cards may differ in panel design, trim fixing points, or switch apertures. Name those years clearly when you contact a breaker and ask them to check the part against your specific registration before buying.
Door cards are fitted to every variant of the W447 V-Class regardless of engine choice, drivetrain, or equipment level — this is not a part that is limited to a specific powertrain. Every door on every V-Class has a trim panel, so you simply need to match the correct generation (pre- or post-2019 facelift), the door type (sliding or hinged), and the side (NS or OS) to find a suitable used part from a breaker.