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No two engines are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The ML (W163) ran from 1998 to 2005, the W164 from 2005 to 2011 with a facelift in 2008, and the W166 from 2011 to 2019 with a facelift in 2015 — these are three distinct generations with very little mechanical crossover. The engine code (found on your V5 or via a HPI/VIN check) is the single most useful detail you can give a breaker, as Mercedes used several different petrol and diesel units across the same badge and year range. Share that code when requesting a quote to avoid being sent the wrong unit.
Both years fall within the W164 generation (2005–2011), so there is a reasonable chance of compatibility if the engine codes match — the 2008 facelift sits within this generation and does not represent a new platform. However, ancillary and mounting changes can occur mid-production even within a generation, so you should confirm against your exact registration with the breaker before purchasing. Always match on engine code first, then let the breaker verify the ancillary details.
The W164 (2005–2011) and W166 (2011–2019) are separate generations with different chassis designs, so an engine crossing that 2011 boundary is not a straightforward swap. Even where the same engine family (for example OM642 diesel) was carried across, mountings, ancillaries and ECU pairing requirements can differ — confirm directly with the breaker against your registration before proceeding. Do not assume a shared engine code means a direct bolt-in fit across a generation change.
On the ML, the trim or specification name (such as SE, Sport, AMG Line) does not affect engine fitment — what matters is the engine code, fuel type, gearbox type (automatic or manual), and year within the generation. The ML250 and ML350 badges denote different engine variants entirely (different codes and displacements), so they are not interchangeable regardless of trim. Trim differences on a shared engine code are purely cosmetic or interior-based and will not affect whether an engine fits.
Yes — fuel type is a fundamental fitment factor, and petrol and diesel engines are completely different units even within the same model year and generation. Within the diesel range alone, the ML has used different displacements and codes (for example the OM642 3.0 V6 diesel in various W164 and W166 variants), so matching the exact engine code rather than just 'petrol' or 'diesel' is essential. Give the breaker your engine code from the V5 or a VIN check to ensure you are quoted the correct unit.
This is a real concern on modern Mercedes vehicles but not something a parts listing can confirm — ECU pairing and immobiliser coding requirements vary and depend on your specific vehicle and the donor unit. You should raise this directly with the breaker and, if needed, factor in the cost of coding with a Mercedes specialist before committing to a purchase. Never assume a used engine will be plug-and-play on the electronics side without checking first.