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No two throttle bodys are quite the same across different vehicles, so getting the specifics right matters when you buy used, second hand or a replacement. Answer a few quick questions below and breakers will only quote if they have the exact matching part in stock:
The W211 (2002–2009) and W212 (2009–2016) are distinct generations with different engine families, so a throttle body from one generation will not simply swap into the other — engine architecture changed significantly across that boundary. Your best starting point is your engine code (found on your V5 or a VIN check), which your breaker can match precisely to the correct unit. Always confirm compatibility with the breaker against your registration before buying.
It depends on the engine variant — petrol E-Class models do use a throttle body as part of their intake and fuelling system, so yes, the part exists on those variants. However, diesel E-Class engines (such as the OM642 or OM651 families) do not use a conventional throttle body in the same way as a petrol engine, so if you drive a diesel E-Class you are likely looking for a different component such as a swirl flap assembly or EGR-related part. Check your fuel type before searching, and if you are unsure what you need, describe the fault to your breaker who can advise on the correct part for your engine.
These are separate generations — the W212 ran from 2009 to 2016 and the W213 from 2016 onwards — and the petrol engines used across them differ enough that the throttle bodies are not a straightforward swap. The engine code is the key detail here, as Mercedes used a range of units including M274 and M276 petrol engines across these years and fitment follows the engine code above all else. Confirm compatibility with your breaker using your exact registration or engine code before purchasing.
No — trim level does not affect throttle body fitment on the E-Class; SE, Sport, AMG Line, and Avantgarde badges relate to equipment and cosmetic specification, not the engine or its ancillaries. What matters is your engine code, fuel type, and the generation of the car, all of which your breaker will use to identify the correct part. The only exception worth noting is if you have a full AMG model (such as an E63) with a different engine entirely, in which case the engine code will make that clear anyway.
The W212 received its facelift in 2013, and while the generation boundary is the same car family, Mercedes did make incremental changes to ancillary components during the production run that could affect fitment across that facelift point. Whether a pre-facelift throttle body is a direct swap onto a post-2013 car is something you should confirm with the breaker against your registration and engine code, as mounting or connector details may differ. Supplying your engine code gives the breaker the best chance of matching the right unit to your car.
On some Mercedes-Benz petrol engines the throttle body requires adaptation or basic settings to be reset after replacement using a diagnostic tool, and in some cases there may be ECU pairing considerations depending on the engine and model year. Whether your specific car requires coding and what that involves is something you should confirm with the breaker and your fitting garage before buying, as this varies and we cannot state it as fact for every variant. Your breaker will often be able to advise based on experience with that engine family.